Introduction to IAV-S

Influenza A virus (IAV) is an orthomyxovirus.1 The genetic material of the virus is made up of 8 segments of RNA containing 8–11 genes, which code for different attributes of the virus (e.g., attachment, replication).2 Influenza A virus in swine (IAV-S) identifies the influenza viruses that have become adapted to swine as the primary host.

Clinical signs of IAV-S

Pigs infected with influenza can display a range of clinical signs, including:3

  • coughing
  • conjunctivitis
  • discharge from the eyes and/or nose
  • sneezing
  • depression
  • anorexia
  • fever
  • lethargy

IAV-S: An ongoing problem for the entire swine operation

Uncomplicated influenza A virus in swine (IAV-S) is a relatively short disease process, but in contemporary production, the disease can linger in the herd for a prolonged period as it continues to find susceptible animals4,5

The clinical signs of IAV-S can be brief in duration, but the impact can last much longer.3,5,6
Disease Timeline * Adapted from Detmer et al.7

References: 1. Short KR, Richard M, Verhagen JH, et al. One health, multiple challenges: the inter-species transmission of influenza A virus. One Health. 2015;1:1–13. 2. Taubenberger JK, Kash JC. Influenza virus evolution, host adaptation and pandemic formation. Cell Host Microbe. 2010;7(6):440–451. doi:10.1016/j.chom.2010.05.009. 3. Vincent AL, Lager KM, Anderson TK. A brief introduction to influenza A virus in swine. Methods Mol Biol. 2014;1161:243–258. 4. Van Reeth K, Brown IH, Olsen CW. Influenza virus. In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, eds. Diseases of Swine. 10th ed. West Sussex, UK: Wiley-Blackwell; 2012:557–571. 5. Pitzer VE, Aguas R, Riley S, Loeffen WLA, Wood JLN, Grenfell BT. High turnover drives prolonged persistence of influenza in managed pig herds. J R Soc Interface. 2016;13:20160138. doi:10.1098/rsif.2016.0138. 6. Janke BH. Influenza A virus infections in swine: pathogenesis and diagnosis. Vet Pathol. 2014;51(2):410–426. 7. Detmer S, Gramer M, Goyal S, Torremorell M, Torrison J. Diagnostics and surveillance for swine influenza. Curr Top Microbiol Immunol. 2013;370:85–112. doi:10.1007/82_2012_220.